MCAM anticorps (PE)

N° du produit ABIN7673692

Cet anticorps anti-MCAM est un anticorps Rat Monoclonal détectant MCAM dans FACS. Adapté pour Souris.

Aperçu rapide pour MCAM anticorps (PE) (ABIN7673692)

Antigène: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp MCAM est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: ME-9F1

Détail du produit anti-MCAM anticorps (PE)

Fonction: PE Anti-Mouse CD146 Antibody

Purification: 0

Pureté: 0

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 % BSA, pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: 4 °C

Stockage commentaire: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur MCAM

Antigène: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Autre désignation: CD146

Sujet:

Synonyms: S-Endo 1 antigen|MUC18|MCAM|Mel-CAM|A32 antigen

Background: CD146, also known as melanoma cell adhesion molecule (MCAM or Mel-CAM), MUC18, S-Endo1, and A32 antigen, is an integral membrane glycoprotein that belongs to the Ig superfamily. CD146 is strongly expressed by murine vascular endothelial cells. It is expressed on about 30 % of neutrophils and 60 % of NK cells. Unlike in humans, CD146 is undetectable on monocytes, dendritic cells, T cells, NKT cells, B cells, or smooth muscle cells in mouse. It has been reported that an increase in CD146 expression is associated with NK cell maturation. Combined with using CD27 and CD11b staining, CD146 may be an alternative marker to detect final stages of NK cell maturation and define NK cell subsets. CD146+ NK cells were found to be less cytotoxic and to produce less IFNγ than CD146- NK cells upon stimulation with target cells or activating antibodies. The role of CD146 on NK cell migration has yet to be investigated. The identification of CD146 ligand(s) will be crucial to address this issue.

Poids moléculaire: 0

ID gène: 84004

UniProt: Q8R2Y2